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Descontos, cupons, promoções e códigos de ofertas são formas de economizar dinheiro em produtos ou serviços. Eles geralmente são encontrados impressos ou online e podem ser aplicados a um pedido durante a finalização da compra, inserindo o código fornecido no cupom. Algumas ofertas do Gshopper podem ser combinadas com outros descontos, promoções ou códigos de frete grátis. Se você estiver interessado em um produto ou serviço específico, não deixe de conferir o site do Gshopper para obter mais informações.

Gshopper

O programa de indicação de um site de comércio eletrônico é uma forma de recompensar os clientes por sua fidelidade e incentivá-los a continuar comprando na empresa. Esses programas podem oferecer incentivos como descontos, mercadorias gratuitas ou vantagens especiais em troca da indicação de amigos e familiares para o site. Dependendo dos termos de um programa específico, as recompensas exatas oferecidas podem variar bastante.

Na Gshopper, acreditamos em manter a experiência de compra atualizada e emocionante para nossos valiosos clientes. Para conseguir isso, introduzimos regularmente novas ofertas e promoções especiais, garantindo que há sempre algo atraente para você descobrir.

Com que frequência você apresenta novas ofertas ou promoções especiais?

Nossa equipe se dedica a estar à frente da curva quando se trata de adquirir os produtos mais recentes e mais procurados. Este compromisso estende-se à nossa abordagem a ofertas e promoções especiais. Entendemos que a variedade é fundamental, por isso pretendemos apresentar novas ofertas semanalmente. Quer sejam descontos exclusivos em eletrônicos de última geração, roupas elegantes ou utensílios domésticos essenciais, você pode esperar algo novo e emocionante a cada semana.

Além das promoções semanais, alinhamos nossas ofertas especiais com eventos e feriados importantes. Isso inclui vendas sazonais, descontos temáticos de feriados e promoções especiais vinculadas a ocasiões como Black Friday, Cyber ​​Monday e muito mais. Esses eventos oferecem excelentes oportunidades para nossos clientes acessarem produtos premium a preços imbatíveis.

Além disso, trabalhamos em estreita colaboração com a nossa rede de fornecedores e parceiros de confiança para lhe oferecer promoções exclusivas. Essas colaborações nos permitem oferecer ofertas exclusivas que você não encontrará em nenhum outro lugar. Quer se trate de um desconto por tempo limitado em uma marca popular ou de um pacote especial, essas promoções exclusivas são projetadas para oferecer um valor excepcional aos nossos clientes.

Para quem deseja ainda mais economia e comodidade, nosso programa de assinatura Gshopper Plus é a solução definitiva. Os assinantes desfrutam de acesso antecipado a ofertas e promoções especiais, o que lhes dá uma vantagem inicial para garantir as melhores ofertas. Além disso, os membros do Gshopper Plus se beneficiam de frete expresso gratuito para pedidos qualificados, garantindo o recebimento de suas compras em tempo hábil.

Na Gshopper entendemos que nossos clientes têm interesses e preferências diversos. É por isso que as nossas ofertas e promoções especiais abrangem uma ampla gama de categorias, atendendo a diversas necessidades e gostos. Quer você seja um entusiasta da tecnologia, um indivíduo moderno ou um comprador de itens essenciais para a casa, você encontrará algo especial esperando por você.

Em resumo, no Gshopper nos dedicamos a proporcionar uma experiência de compra dinâmica. Ao apresentar regularmente novas ofertas especiais e promoções, garantimos que há sempre um motivo para explorar a nossa seleção selecionada de produtos de alta qualidade. Junte-se a nós hoje e experimente a emoção de descobrir ofertas fantásticas no Gshopper.

Descubra o mundo emocionante da coleção de cartas do Gshopper: cadastre-se agora e ganhe US$ 500 em presentes incríveis

CODE: GPSEP8 100-8
CODE: GPSEP15 200-15

Sometimes, we think that our boyfriend is, in fact, cheating on us, but we don’t really have any evidence. We suspect he’s calling another woman, but all his calls are on his cell phone and there’s no way we can access the information. What if there was a way to find out who he is calling? Finding the truth about a boyfriend can be difficult, but there is an easy way to find out the truth. By using a reverse phone lookup, you can access his cell phone information to find the facts. This is how you do it.

The first thing you are going to need is your boyfriend’s cell phone. This can be done by asking him or even by staying up until he falls asleep. Once you have his phone, he writes down about 10 numbers that look suspicious to you. These could be numbers that are not registered to your phone, or they may have a unique name.

After you’ve written down all of these numbers, you’ll need a reverse phone verification. This can be found anywhere on the internet, but you need to make sure that you provide these three important factors

#1 – You need to be able to access cell phones, landlines, and even unlisted numbers

#2 – Must be constantly updated

#3 – It has to be reliable and provide accurate results

Once you’ve found a reliable reverse phone lookup, simply type the numbers into the boxes and wait for the results. Here you can find out the name and where the girl lives. You’ll also be able to look up criminal records, warrant searches, and even phone numbers that are also associated with the same account.

Viral marketing refers to a marketing technique that uses social media to expand brand awareness and achieve other marketing goals. It can be transmitted by word of mouth or with the support of the network effects of the Internet. Viral marketing is done in the form of video clips, interactive flash games, media, e-books, branded software, images, or text messages.

The goal of marketers who embrace viral marketing as a method of increasing brand awareness and other goals is to create messages that appeal to people with high social networking potential (SNPs) and have a high probability of being featured and disseminated by these individuals and their competitors in their communications with others in a short period of time. It is basically a marketing phenomenon that facilitates and encourages people to convey a marketing message.

For viral marketing to work, three basic criteria must be met, that is, delivering the right message to the right messengers in the right environment:

Delivery courier

To transform an ordinary message into a viral message, three specific types of messengers are required: market experts, social hubs, and salespeople.

Market experts are people who are information specialists; They are usually among the first to know the message and those who spread it in their immediate social network.

Social hubs are people with a large number of social networks. They act as a link or bridge between different subcultures as they often meet hundreds of different people.

Sellers are the people who receive the message from market experts, enhance it by making it more engaging and moving, and then forward it to the social hub for further distribution. Market experts may not be particularly convincing in conveying the information.

Message

Only a message that is memorable, compelling, and interesting enough to pass on to others is capable of fostering a successful and healthy viral marketing phenomenon. Small adjustments can make a big difference and cause an expansion of the viral marketing sphere.

Atmosphere

Small changes in the environment strongly affect the results, and people are much more sensitive to the environment. The timing and context of the campaign launch must be chosen wisely.

The methods used for viral marketing are:

Customer engagement and survey services Contributions from industry-specific organizations Internet search engines and blogs Mobile smartphone integration Multiple forms of print and direct marketing Outbound/inbound call center services Targeted marketing Web services Search engine optimization (SEO) web development Social media interconnectivity Television and radio

Christians around the world readily accept creationism, Jesus the son of God, the virgin birth, the resurrection. Its acceptance is due to ‘blind faith’.

Realizationism like Christianity also requires this blind faith. So an open mind is important when exploring this new concept.

How did humanity evolve so quickly during the Holocene era to become an integral part of the Earth’s fabric? Throughout history, why have humans always been so smart?

This introduces the key leap of faith in Realization:

Is the arrival of extraterrestrials on our planet in our prehistory the only logical and common sense explanation for our truly remarkable evolution from the indigenous people? Homo sapiens/ Neanderthal species during such a short period?

Did they genetically experiment with various deceivers on Earth to suit their purposes? Did any of these experiments involve genetic manipulation of our Homo sapiens ancestors, perhaps our mitochondrial DNA, creating the human race? According to Darwin’s theory, those Homo sapiens possessing the alien visitor gene had a significant advantage and began to replace those without it, resulting in a dramatic shift in human evolution. The highly intelligent human race then rapidly evolved from this distinctive “Eve” point.

Was this ET-inspired civilization, which built pyramids on every continent on Earth, destroyed by a tsunami (possibly caused by an asteroid) that occurred around 8,000 years ago – ‘Younger Dryas Global Event’ – also described in the book Noah’s Flooddevastating this incredible early civilization, starting “The Planet of the (intelligent) homo sapiens“?

We share 98.4% of the genetic makeup of our closest relative, the African chimpanzee. Is it likely that in 8,000 years the chimpanzee will be able to design, build and drive a car? The answer is yes, but only with genetic manipulation on our part!

Now we come to the interesting part: a group of our first human survivors, perhaps Noah, who as a leader, understood and witnessed this amazing first civilization. Did he, along with other leaders, save much of the incredible knowledge and records run by ET? We assume that the ‘Ark’ is a large ship where Noah brought the animals “in pairs”. Was it logical to save animals in the event of a global disaster? Has this word ‘ark’ been deliberately misinterpreted? Sounds like another red herring? Was the “Ark” more likely to be some sort of storage facility, perhaps one of the surviving pyramids in Egypt with the information moved long ago to a more secure secret location?

Was this information/knowledge, after the devastation that occurred after the massive destruction of our planet, extremely important to the survival of the leaders through the manipulation of the confused remaining survivors?

Has our early ET civilization been deliberately obscured by a group of ‘Elites’ who knew about ET and have continually hidden and distracted this from us in order to have power over the rest of us from now on?

This is not a new question. It has been explored through generations and is even mentioned in the Bible and cleverly depicted in the Monty Pythons movie “Life of Brian” which was strangely banned by the Church.

It seems our understanding of humanity has been deliberately restricted to creationism, begrudgingly expanded by Darwinism in the 19th century and then by intelligent design with the ever-present ‘Nature vs. Nurture’ debate.

Creationism, then Darwinism, and now is the opportune moment to discover a new possibility of understanding our non-Darwinian human progress through Realization!

I believe that we can change humanity for the better by advancing this concept of ‘realization’ in our goal of understanding our being!

So what is Realization?

1. The conscience we have ALL inherited a transgenerational ‘alien memory gene’ located in our unconscious mind that contains universal knowledge going back to the universe and creation.

2. ALL Human beings are very valuable.

The words Humanity, Equality, Diversification are now commonly used.

3. We know everything unconsciously but we don’t know everything.

This blind faith that we know we have all the knowledge in our unconscious memory (like Microsoft’s operating system). Is there any consolation in believing that we already know everything? Does this make us fearless in both life and death knowing that we have the potential to eventually know everything even though at this stage of our evolution we don’t?

Do we already have all the answers to the birth of the Universe – ‘Inflation’ and the energy of the ‘Grand Unification’ still hidden in our unconscious memory?

Realizationism like creationism requires faith!

4. The recognition that our subconscious mind/memory is constantly being manipulated by the ‘Elites’!

So, we must first realize that there are elites among us who rule our planet. Your ancestors had figured out some time ago how to manipulate and control our collective subconscious minds by primarily playing on our fears and greed. This has created his continued success! See ‘Humanity, our extraterrestrial past’ article.

They likely evolved from a long line of secret societies: Knights Templar, Freemasonry, etc., with the intent of preserving the remnants of an elite Aryan-type race from an extraterrestrial colonization of Earth some 13,000 years ago.

5. Achievement leads to Personal Transition. Live a life that is real and does not contain us. There is no dress rehearsal, this is it!

With this new found freedom of mind, we can dismiss the negative manipulative propaganda that is often irrelevant to our individual lives! Ask where your loyalties, superstitions, and beliefs come from. Take control and, when and where possible, try not to take life too seriously. Be positive, have fun!

Every day there are more people writing books, music, painting, in other words, discovering their own creativity!

6. We can regain control of our subconscious from the ‘Elite’. We can easily peel away the layers of ‘baggage’ and conspiracy accumulated over the centuries around our collective unconscious minds that are holding us all. We can become truly present to what is happening.

Many people on the planet who are not really here never really connect in a meaningful way with the world!

Realizationism is a individual mental process to regain control of our subconscious and collective subconscious from the manipulative elites.

So our approach can be described by the experience of Viktor Frankl, a Jewish psychologist who ended up in Auschwitz during the Holocaust era. He survived the horrors by clinging to the idea that even if suffering is inevitable and inescapable, he will never be able to. Take away your inner freedom face it with courage and dignity.

Frankl survived these ordeals during the war to become head of the department of neurology at the Vienna Polyclinic Hospital.

We don’t need to PUT THE HEAD ON THE BARAPET. There is no need to participate in protest marches or become a whistleblower. Many brave souls have been ‘boiled’ and threatened or worse and, in the case of whistleblowers, exposed and their reputations and careers irrevocably damaged. We just need to control our subconscious to ‘go on strike’ when we recognize that we are being manipulated!

Until ‘Brexit’ there was no real democracy. Alex Geairns’ book ‘Mindful’ highlights how we can change the government tailored by the establishment run ‘Elites’ in this ‘Westminster bubble’. Realism can provide a backdrop to understand why the political landscape must change to become more democratic!

If we could positively influence how our lives are manipulated through Realization, then impositions like fracking, untested drugs, and the other compromises that are forced upon us would soon stop. THEY STILL NEED US!!

Examples of Realizationism:-

“When you call yourself an Indian, a Muslim, a Christian, a European, or anything else, you are being violent. Do you see why it is violent? Because you are separating yourself from the rest of humanity. When you separate yourself by belief, by nationality, by tradition, it breeds violence. So a man who seeks to understand violence does not belong to any country, to any religion, to any political party or partial system; he is concerned with the full understanding of humanity.” Jiddu Krishnamurti

Does this mean, through our understanding of Realization, that ‘man’s inhumanity to man’ will disappear?

Another example in the famous poem by Robbie Burns: A man is a man for that. Verse five is a prayer that meaning and value will eventually agree with all mankind. Burns envisions a future world in which all people will live as brothers, in mutual trust and respect. “He’s still coming, for that.” Well, Rabbie hasn’t arrived yet, but we can help him on his way!

Nelson Mandela defeated the ‘Whites’ who were seen by him and his people as ‘Elites’. Mandela – freedom fighter to president. Unstoppable by whites but possibly not by elites?!

Our ability to collaborate separates us from all other creatures on Earth. The introduction of the transistor, the ‘silicon’ chip and, in turn, the Internet has rapidly increased our ability to collaborate and thus the rapid increase in our creativity and knowledge. Is credibility and our use of the Internet slowly eroding? The ‘Elites’ don’t like to see groups as an even better platform for sharing ideas, encouraged by the World Wide Web!

Was allowing the internet to happen an accident? Has the introduction of the Internet by elites to monitor us more closely failed? Did the elites not realize the power of the Internet? Or maybe the compensation for having the opportunity to collaborate on the World Wide Web is a calculated risk?

Is the Internet unstoppable, to be recognized as an important tool in Realism and our ascent in knowledge down the bathtub curve towards a better humanity? Or is there a secret agency that has granted major hackers amnesty if they can crack Microsoft’s operating system and thereby drastically limit our ability to use the Internet?

So, we don’t have to be manipulated. TO DO WITHOUT!! Maybe sometimes it’s not easy!

If you are not satisfied with the media propaganda? TO TURN OFF!!

Realizationism, of course, is already happening. A good example is in sports. At the recent Commonwealth Games in Glasgow we witnessed athletes with the attitude “Anything is possible!” We also saw a greater awareness of self-discipline, dignity, generosity and personal responsibility, intrinsic to the ideal of Realism.

For some of us, it is important to be aware of Realization.

So Realization is not a new idea. I just put a tag on it!

I don’t think we’re going to be saved by an outside force. We need our individual presence in the world to solve our own dilemmas.

It may not be possible to achieve world in peace thanks to the Elites, but through Realization we can fight for Peace in the world.

Will the introduction of Realization inspire the next phase of our Humanity at the beginning of bear exploration of the universe

If you want to quit smoking, you’ll need all the help you can get, including friends, family, and your own temple of success.

Just imagine having a place where you can go, where you are completely safe and can create all the changes you want in your life. A place where you could easily and quickly make changes.

As you read this, imagine a great old temple unfolding before your eyes, maybe like in an Indiana Jones movie, but of course without the snakes and crushing rocks.

You walk through the jewel-encrusted halls and enter a beautiful room. In the middle of the room is a circle. In the circle is a gold tablet with a word inscribed on it. Maybe it says strength, or power, maybe confidence.

This word will help you quit smoking. You step into the circle, bend down and pick up the tablet and take a deep breath of the word. Then you walk out of the circle taking the tablet with you, absorbing the meaning of the word into your own cells.

You then repeat the process as many times as necessary to feel empowered, and then do it again another day if necessary.

You then continue exploring the temple until you find another room. You walk in this one has three people. You are left feeling a sense of security because each of them is someone you know or would like to meet, each of whom has a special message of support for you.

You approach them one at a time; you listen to their advice and personal messages for you and then you embrace them. Consider your words and how they will help you quit smoking.

The message can be clear or it can be cryptic, it only makes sense to you later. You can continue to explore your temple and note any other messages or offers of help. Knowing that you can return at any time you need it.

This whole process may seem too magical or maybe just ridiculous, but consider that it is just a way to activate your mind and access your inner knowing, to allow yourself the freedom to follow what you already know and understand on a deep level.

Of course, your temple can be used anytime you want to build the courage to move on in your life and put the past behind you.

Would you like to reduce the electrical costs associated with your compressed air system? Most likely you can. Start by determining your annual compressed air electrical costs using this formula:

Brake Horsepower X 0.746 X Annual Running Hours X KWH (Kilowatt-hour) Cost (divided by) Motor Efficiency

NOTE: 1 CFM (cubic feet per minute) @ 100 PSIG (pounds-force per square inch) PER 8760 HOURS COST $110.00 PER YEAR IN ELECTRICAL COST

Next…follow these top 7 tips to save energy with compressed air:

1. Fix your air leaks

If you do nothing else, follow this tip: find and fix your compressed air leaks. Air leaks are the “biggest losses” in the industry!

The average plant loses 20-30% of its compressed air through multiple small air leaks. The money spent on labor and parts to find and fix these leaks is well worth it. Note (1/4-inch orifice will flow 103 cfm at 100 psig)

2. Change to Synthetic Lubricants

If you are using petroleum-based lubricants, you could experience up to 8% energy savings by switching to synthetic compressor lubricants. Plus, extend equipment life and save on oil changes and disposal costs.

3. Reduce the operating pressure of the plant

If possible, reduce overall plant pressure. Less pressure > Less CFM used > Less power consumed.

TIP: Reduce plant pressure 2 pounds at a time, then test run for a minimum of 24 hours. If any equipment is having trouble… increase pressure 2lbs until it runs smooth again. For every 2 pounds of pressure reduction, you save 1% of the electrical cost to run the air compressor.

4. Check differential pressure across air compressor filters.

Start at the compressor cabinet filter and then check the compressor inlet filter.

Note: A dirty inlet filter can cost you 1-3% in additional electrical costs. Because? Because decreased airflow to the compressor inlet valve increases compression ratios, resulting in more run time.

Next, check the differential pressure of the air/oil separator at full load. A new separator causes a differential pressure drop of approximately 2-3 psig. When your pressure drop reaches 8-10 psig, then it’s time to change the separator elements. A dirty separator element can cost you up to 5% in additional electrical costs.

Then change the control air filter element. This is often overlooked, but it’s still an important filter where the controls receive their air signal. A pressure drop here causes the controls to receive the lower pressure signal loading the compressor more and using more electricity.

5. Reduce compressor inlet temperature

By reducing the intake air temperature 10°F below 70°F, you save 2% on electricity usage. Your profit increases up to 8% on a 30°F day. But raising your inlet temperature 10°F above 70°F will cost you an additional 2% in electrical usage for every 10°F up to 10% at 120°F. (Inlet temperature has very little effect on lubricated screw compressors)

6. Check differential pressure across compressed air line filters.

Size compressed air filters to be twice (2x) the CFM flow rate of your compressor. This will reduce your pressure drop by approximately 2-3 psig and save 1% on energy costs. Elements will last twice as long (2x) and you’ll save on maintenance costs.

7. Know what quality of compressed air your plant needs.

The cleaner and drier the compressed air, the more energy it will use.

Check with your equipment manufacturer to determine the required air quality.

Technology has dramatically changed the way we live today, there’s no denying it. Compared to our ancestors, we are far removed from them in the use of different technologies for our daily work.

So many technologies have been developed in recent years that have revolutionized our lives, and it is impossible to list each one of them. Although technology changes rapidly with time, we can observe the trends in which it changes. Last year 2016 brought many innovative and fresh ideas and creations towards automation, integration etc., and this year 2017 is expected to continue a similar trend.

In this article we are going to discuss some of the outstanding trends for this year, which will make us look beyond the horizon.

Gartner’s 2016 Hype Cycle for Emerging Technologies has identified a number of technologies that will be trending this year. The cycle illustrates how technological innovations are redefining customer-retailer relationships.

This year, Gartner has identified Blockchains, connected homes, cognitive expert advisors, machine learning, software-defined security etc as well as broader technology trends, which have the potential to reshape business models and offer companies the definitive route to emerging markets and ecosystems.

#1. block chain

Popularly known as ‘Distributed Ledger Technology’ for both financial and non-financial transactions, it is one of the perplexing concepts that can only be fully understood by technologists. Various advancements in blockchain have helped many people and more companies in 2016 to experience its potential in the banking and finance industry. This year, it is anticipated that blockchain technology will go beyond the banking sector, helping new and established companies address market needs with different application offerings.

#2. Internet of things and smart home technology

With the advent of IoT, we are already looking at the world of interconnected things, aren’t we? Our dreams of living in smart homes are fulfilled to some extent in 2016. So what is stopping us from fulfilling our dreams of living in connected smart homes?

Well, the fact is that the market is full of abundant individual devices and applications, but only a small number of solutions integrate them into a single and inclusive user experience. It is expected that 2017 will notice this trend to take a big step towards fulfilling our dreams.

#3. Artificial intelligence and machine learning

In recent times, artificial intelligence and machine learning have conquered the entire world with their amazing inventions and innovative technologies. Looking at the ongoing advancements in this field, it will no longer be an imagination to experience the world where robots and machines will dominate the society.

Last year, we witnessed the rise of ML algorithms on almost all major e-commerce portals and their associated mobile apps, which is expected to spread to all social media platforms, dating websites, and marriage websites. in 2017.

#4. Software Defined Security

In 2016, we have seen significant growth in increasing server security. Many organizations have begun to recognize the importance of cybersecurity to enable their movement to emerge as digital businesses. The growth of cloud-based infrastructure is causing a huge demand for unstructured data management, and furthermore, the lack of technical expertise and the threat to data security are the key factors hindering the substantial growth of the cloud computing market. software-defined security this year.

#5. Automation

Automation will be the mainstay throughout 2017, the next few years will be transformative for the IT industry, allowing the automation of tasks performed by humans. When machine learning is combined with automation, marketers are likely to witness vast business opportunities with enriched market outcomes.

#6. Augmented Reality (AR) and Virtual Reality (VR)

AR and VR transform the way users interact with each other and with software systems. The year 2016 has seen revolutionary advances in AR and VR technology.

With the launch of the Oculus Rift, the market received an overwhelming response from users, giving way to a large number of VR-based apps and games. Also, when Pokémon Go was released, the definition of gameplay was completely redefined. It was one of the most profitable and downloaded mobile apps of 2016.

The response that AR and VR technology received last year was over the top, and it forecasts that the world is ready to take this trend to the next level in 2017.

#7. services on demand

Since the last few years, the global market has experienced a great response for on-demand services. Thanks to startups like Uber, Twiggy, etc. which started the fleet of offering on-demand taxi services and food delivery services with just a few clicks. This trend has triggered the development of various mobile applications, which offer multiple on-demand services at your fingertips. Although these services were limited to defined regions, they are expected to reach peak locations in 2017.

#8. smart apps

Smart applications include technologies using personal digital assistants (PDAs) that have the caliber to transform the workplace into a more interactive one, with effective communication. By using artificial intelligence technology, service providers will focus on autonomous business processes that will make full use of big data tools, to improve customer experience levels.

#9. Humanized Big Data (Visual, Empathetic, Qualitative)

Since the past few years, Big Data has been the big topic and created a buzz in the global market. The intent is that the massive amounts of collected data, to which we have access, can help us in every little thing, that is, from planning advanced medical treatments to deploying exceptional business promotion strategies.

Big Data’s greatest strength is its quantitative and numerical base, which is also a great weakness. When experiencing the success that Donald Trump had in the US elections, a big question arises about the analysis of Big Data and its practice in decision making. Big data in 2017 is expected to experience great advances, which will help marketers to humanize themselves and look for empathic and qualitative bits of data to project them in a more visualized way.

What do you think of these emerging trends?

Most of us know that making assumptions is generally an amazing feat, but literally predicting something related to future technology over the course of a year is an exercise in futility. There may be additions to the above-mentioned trends, but the above-mentioned ones are more likely to attract market attention in 2017. This forecast will certainly help marketers plan their future business strategies and deploy the right resources having proven experience in these technologies

I turned 61 in July. The other day I sat in an admissions office to go back to school. I’m going to finish my college degree after, oh, about three dozen years of ‘off-campus study’ aka real life. teachers? Doctor? My gap year? No, the basic bachelor’s degree was left unfinished, hanging in the air since 1967. In my case, really hanging in the air, since, in the intervening decades since I crossed campus, I paid the bills with a flight career.

So why this. And why now? Vanity? Boredom? The desire to surround myself with pretty students? None of the above. The dresser took off a while back, along with my six pack that now looks like that guy from Pillsbury; boredom either, as life gets more exciting the closer you get to the end, and if you don’t believe it, you’re under forty. The students? Please. It takes some men thirty years to realize they’re not 20 anymore. Not me. I am happily off the market, happily married to the most attractive and beautiful woman on the planet. As Paul Newman said, why have burgers when you can have steak at home? Also, who is fooling whom? I hope they call me OGOC, Old Guy On Campus, really.

So why come back? My wife said it best: you’re turning 65 anyway; Why not get your diploma and start Social Security the same day? Tempting prospect, I thought. First it was the post-war GI bill, now another double-dip opportunity. Cool. A lovely girl, my wife, and so smart. I wondered why she wasn’t the one looking for the title instead of me. But she has a sheepskin and I don’t. Reason enough? No, but it illustrates the different vectors of our lives, and since I turned 60, and since I was in mid-retirement, I saw the point of it: why not now? I have time; I am inclined as the credit itch never went away; I have the money, the lack of which is more or less the reason I dropped out of college all those years ago, that and grades which, ahem, were also woefully lacking. Then came Vietnam, marriage, kids, mortgages, the whole gamut, all of which pushed college into the background.

Until now. A recent walk across campus ignited my old ambition, and one thing led to another, and I soon found myself talking to an adviser a third of my age about, gulping, trying again.

This, along with those listed by my spouse, is one of the reasons I choose to return to college. In short, I have experience to share. In other words, among the elderly and everyday, the vast majority of people, there has always been a rather bitter view of those in society lucky enough to spend their days in the idyllic, so-called ‘Ivory Tower’ of the academy. It may be jealousy, it may be envy, but for people in a nine to five world, the prospect of classes, books, the university environment and, of course, the party atmosphere represent a mythical part of life that, by its nature, ephemeral. , draws scorn from those whose weekly high point is Friday afternoon, especially if it’s payday. I’m arrogant enough to believe that I can be a resource on that campus. Maybe not to fellow students (I still marvel at that title), but to those charged with teaching things like the three ‘R’s, reading, writing, and real life. I’d like to think that I can add a little nuance in that classroom. This is not something I could have offered at 21, 41, or even 51. Now? I would like to think that my exposure to real life in these last forty years since the winter term of ’68 is useful and sought after by some who are truly eager to learn, which is the prospective purpose of the university, after all. I’d like to think that I can add a measure of perspective and truth to hypothetical propositions. And, I’d like to think, that’s by itself reason enough since, in my humble opinion, there’s a dearth of that particular activity in our cacophonous marketplace right now.

Obviously I’m not alone. Depending on definitions, ‘non-professionals’ made up a staggering 63% of the student body these days. There are a lot of returning veterans, a lot of young people on a gap year, and a lot more laid-off, downsized, and retrained workforce members than ever before sitting in those admissions offices like me. Plus, I’m a boomer, and everyone knows we’ll never grow up, never admit we’re old until we start drooling in our socks, and even then…

The presence of these nontraditional students, especially military veterans, enriches the classroom, many teachers say. As for veterans like me: “They’ve seen the world, faced incredible dangers, and had to make decisions that few civilians have had to make. That helps other students see the world in a more nuanced way.” according to Daniel Byman, director of the Center for Peace and Security Studies at Georgetown University in Washington, who recently addressed the issue in the Chronicle of Education. In my own case, having flown a helicopter in Vietnam, and then from the cockpit of a medical helicopter for twenty years, I have seen things, done things, gone places, and made decisions that none of those handsome students could. dream. above.

So hello hello, I’m off to class, and as far as I’m concerned, it’s never too late. To my fellow semi-retired boomers or not, give it some thought. As my wife says, you’re going to be 65 anyway. More gray heads in the graduation line can only be a good thing. There’s even a kind of Darwinian component: those younger guys, the jocks and frat boys, the guys who aren’t old enough to understand that the bill of your cap is supposed to protect your face, not the back of your neck. , they may need to exhibit a little more maturity when we’re around. Many cultures revere their more experienced class; maybe we can bring that idea closer to reality here by a degree, or two, or three…

Mast cell enterocolitis is a new clinical entity characterized by an increase of 20 or more mast cells per high-power field in the duodenum or colon. Jakate et al. described 47 patients with intractable diarrhea and abdominal pain of no other cause who had elevated mast cell counts on intestinal biopsies and responded to mast cell-directed therapy. Patients generally met criteria for diarrhea-predominant irritable bowel syndrome (IBS). Normal subjects had much lower levels of mast cells than an average of 12 per HPF. My experience indicates that this condition may be another hidden epidemic to be added to that of celiac disease and non-celiac gluten sensitivity (NCGS). My colleague, Dr. Rodney Ford, suggested the term “gluten syndrome” for the broader problem of non-celiac gluten sensitivity, and I agree that this may be a more appropriate term. Now, he suggests that mast cell inflammatory bowel disease (MIBD) be considered a better term for the newly recognized mast cell enterocolitis.

Until recently, the presence of increased mast cells was either overlooked due to a lack of ability to see mast cells in biopsies in the background of normal cells or only noted in association with inflammatory bowel diseases and celiac disease. Some pediatric studies have observed increased mast cells in the esophagus in association with eosinophilic esophagitis or “allergic esophagus”. Systemic mastocytosis has been known for years and has been associated with intestinal symptoms such as abdominal pain and diarrhea. Now, two new studies shed more light on this covert cell and its role in postoperative ileus and its association with stress. Mast cells have been associated with diarrhea-predominant IBS in some studies, but it was not until Jakate’s article that a distinct entity was defined.

The problem of linking mast cells to IBS and other digestive symptoms has been compounded by the difficulty in seeing these cells in intestinal biopsies. However, special stains now commercially available using immunohistochemistry for the enzyme tryptase make it possible to see and count mucosal mast cells in intestinal tissue obtained from routine random intestinal biopsies. For the past year I have been asking pathologists to perform mast cell stains on intestinal biopsies in my GI patients with diarrhea and abdominal pain. I recently began expanding this to include as many patients as possible, as well as requesting that these stains be done on biopsies previously done on patients I suspected might have this condition.

I have now accumulated fifty patients who meet the criteria for mast cell enterocolitis or mast cell enteritis. These patients are in various stages of evaluation and treatment. I am collecting and analyzing clinical information with the intention of submitting the data for publication. What I observed in the initial review is that there appears to be a higher than expected prevalence of the celiac disease risk genes DQ2 and DQ8. In particular, DQ8 appears to be overrepresented compared to the incidence in the general population. There also appears to be an association with celiac disease, non-celiac gluten sensitivity, and multiple food intolerances.

The latest finding of multiple food intolerance determined by abnormalities in mediator release tests (MRT, Signet Diagnostic Corporation, and Alcat) makes sense. The principle of these tests is the detection of changes in cell volumes that occur due to the release of a chemical mediator from the cells present in the blood. The tests are not specific to the mediator(s) released, but it is assumed that the larger the reaction, the greater the number of mediators released and the more likely it is that a particular food, chemical, or food additive could cause an adverse reaction. .

Laboratories that provide mediator release tests report great success in treating a variety of symptoms commonly attributed to food intolerance or chemical/additive sensitivity. I think mast cells are very involved in this process. This would make sense since success with conditions now associated with mast cells is reported to respond favorably to dietary elimination of foods or substances with abnormal MRT reactions. Classic examples include IBS, headaches, and interstitial cystitis which have been linked to mast cells, as well as stress which is now linked to increased mast cells and mast cell-releasing mediators of degranulation.

Mediator release tests, particularly quackwatch.com, are criticized by some US physicians for not being tested or validated for the evaluation of “food allergies.” However, they are not food allergy tests. Food allergy is an immediate IgE-mediated type I immune response known as allergy. MRT tests for non-immune delayed-type reactions resulting from the release of mediators from immune cells. The point is that the mediator release test is not a form of food allergy testing. MRT is a form of non-immune food intolerance or sensitivity reaction.

New articles published in the January 2008 issue of the journal Gut reveal exciting new associations of mast cell degranulation with postoperative ileus and a link to a stress hormone. The first study may be the first to show that mast cells in the human intestine release mediators when the intestine is manipulated during surgery, resulting in temporary intestinal paralysis known as postoperative ileus. The minimally invasive surgical technique of laparoscopy results in less mechanical stimuli to the bowel and has a lower incidence of postoperative ileus.

The association of stress with IBS and inflammatory bowel diseases (ulcerative colitis, Crohn’s disease) has been known for a long time, but a mechanism has not been definitively determined. In the same issue of Gut, the researchers demonstrated that the stress hormone, corticotropin-releasing hormone (CRH), regulates intestinal permeability (leaky gut) via mast cells. The researchers even identified specific receptors on mast cells. This new information sheds new light on the possible link of leaky gut and mast cells to IBS, IBD, and celiac disease.

So how do I think this new information can help us? Since stress can increase mast cells in the intestine and these cells can release mediators that cause intestinal lesions and symptoms, stress reduction is important. These cells can cause abdominal pain, diarrhea, and constipation, as well as other symptoms outside the intestine, so they are important. However, the importance of these cells is generally not recognized because most physicians, including gastroenterologists and pathologists, are unaware of their presence and importance.

These cells cannot be seen in the intestine without special stains performed on intestinal tissue obtained during upper GI endoscopy or colonoscopy. Those stains are not routinely done, but usually require the doctor performing the biopsy to order them. If a biopsy is not done, obviously these cells cannot be found. There may be a genetic predisposition for what I think may be a better term for mast cell inflammatory bowel disease (MIBD) rather than mast cell enterocolitis. There may also be the same genetically determined white blood cell protein patterns that are associated with celiac disease and play a role in MIBD.

As stated above, stress reduction and probiotic therapy can be helpful in reducing mast cells and leaky gut, but what happens once mast cells increase in the gut? Once there are elevated mast cells, treatment may include medication and dietary interventions. Antihistamines, both type I (eg, Claritin, Allegra, Zirtec) and type II (eg, Zantac, Tagamet, Pepcid) to block the effects of histamine have been used successfully to reduce Abdominal pain and diarrhea in people with mast cell enterocolitis. A very specific mast cell stabilizer, Cromalyn sodium (Gastrocrom), also reduces symptoms. It is an accepted therapy for the more severe condition of generalized mastocytosis.

In my experience, it is also helpful to screen for food allergies and intolerances (by mediator release testing), followed by dietary elimination of problematic foods until leaky gut resolves and the number of mast cells in the gut is reduced. Food allergy testing consists of skin tests and IgE RAST antibody tests. These tests do not exclude non-allergic food intolerance and sensitivity. Antibody tests for IgG in blood or IgA in stool or saliva have been used for food sensitivities. In my experience, MRT tests are much more useful, looking for any abnormal release of mediators in a variety of foods, chemicals, or additives, regardless of nature.

Stay tuned for new developments on the role of mast cells and look for more interest in mast cell enterocolitis in the future. I propose that the GI community should adopt the broader term mast cell inflammatory bowel disease as there is information indicating that mast cells play an important role in allergic problems of the esophagus and stomach.

Selected references:

El, FO et al. “Mast cell activation and inflammation induced by intestinal manipulation in human postoperative ileus”. gut 2008; 57:33-40

Valon, C et al. “Corticotropin-releasing hormone (CRH) regulates macromolecular permeability across mast cells in normal human colon biopsies in vitro”. gut 2008; 57:50-58.

Jakate, S. “Mast Cell Enterocolitis: Increased Mucosal Mast Cells in Chronic Intractable Diarrhea.” Arch Pathol Lab Med 2006; 130:362-367.

Copyright 2008 Dr. Scot M. Lewey http://www.thefooddoc.com

Hello people, I hope you are well today!

We’ll jump right into it and talk about what the title of this article implies: virtual glasses to make your 3D dreams come true. Virtual reality, that is.

I have wanted, many times, to be able to watch my favorite games or movies that I like to watch in the form of virtual reality, but every time I look for some kind of solution, I am left with a cheap imitation of 3D. glasses that are useless and the cinemas collect them as if they were candy.

I’m tired of it. I wanted something else. I wanted to literally FEEL the experience. I wanted it to feel like it was there.

When Frodo Baggins was destroying the one ring, he wanted it to feel like he was there, not like he was seeing it in “3D”.

He wanted to feel like she was literally there, with him, as he fought Golum and his own desires to keep the ring, while he tried to get rid of it.

So, I did what most of us would do in this situation: I searched. I searched long and hard, and found many things that said they could do what I wanted, but in the end, they gave empty promises.

He knew that what he needed was something more. She needed more than 3D glasses. She needed virtual glasses.

With virtual glasses, I can walk in like I’m really there. It makes a big difference. It’s amazing what I feel, see and experience now during movies and games. It’s like a completely different experience.

If this trend continues, I am fully confident that the technology will continue to increase, and in a few years, we will be able to literally feel what we are experiencing.

With virtual glasses, it’s like you’re there. I can play my favorite games (Final Fantasy 7 is one of them), and I can experience Cloud, Tifa, Sephiroth, etc… in all their splendor, like I always wanted. I’m going to see Cloud brandishing his huge sword like he’s really there. He is crazy.